# Discovery Loop Evidence Review

**SKU:** CAIN-A75-003  
**Development:** #3 Closed-loop experimental discovery  
**Product status:** DELIVERABLE  
**Engine:** `discovery_loop` (`cain_a75_engines/discoveryloop/engine.py`)  
**Profile:** `aptamer_campaign`  
**Generated:** 2026-11-12T07:59:08Z UTC

## Result

SUPPORTED over 3 cycles; 33/33 record-failure cases as expected

- **aptamer_screen_3_cycles**: SUPPORTED
- **valid_cycle_1**: SUPPORTED
- **valid_cycle_2**: SUPPORTED
- **valid_cycle_3**: SUPPORTED
- **missing_fact_class**: NOT_SUPPORTED
- **invented_fact_class**: NOT_SUPPORTED
- **observed_without_measurement**: NOT_SUPPORTED
- **observed_cites_unknown_measurement**: NOT_SUPPORTED
- **missing_raw_data_hash**: NOT_SUPPORTED
- **claim_contradicts_its_measurement**: NOT_SUPPORTED
- **metric_mismatch**: NOT_SUPPORTED
- **observed_cites_two_measurements**: NOT_SUPPORTED
- **verified_on_one_instrument**: NOT_SUPPORTED
- **verified_replicates_disagree**: NOT_SUPPORTED
- **verified_with_one_measurement**: NOT_SUPPORTED
- **cherry_picked_measurement**: NOT_SUPPORTED
- **exclusion_without_reason**: NOT_SUPPORTED
- **excluded_measurement_loses_raw_data**: NOT_SUPPORTED
- **revision_on_hunch_only**: NOT_SUPPORTED
- **revision_on_counterfactual**: NOT_SUPPORTED
- **revision_cites_nothing**: NOT_SUPPORTED
- **derived_from_counterfactual**: NOT_SUPPORTED
- **derived_without_method**: NOT_SUPPORTED
- **derived_from_unknown_claim**: NOT_SUPPORTED
- **derived_from_hunch_only**: NOT_SUPPORTED
- **circular_derivation**: NOT_SUPPORTED
- **counterfactual_with_measurements**: NOT_SUPPORTED
- **cites_a_future_measurement**: NOT_SUPPORTED
- **observed_cites_previous_cycle**: NOT_SUPPORTED
- **nan_value**: NOT_SUPPORTED
- **string_value**: NOT_SUPPORTED
- **duplicate_measurement_id**: NOT_SUPPORTED
- **wrong_schema**: NOT_SUPPORTED
- **garbage**: NOT_SUPPORTED

## Limits of this run

Checks the discovery record supplied (fact classes, evidence links, replicates, exclusions, strategy revisions). It does not re-run experiments and does not prove a measurement was real. The run is Ed25519-signed; pin the issuer key out of band.

This is a bounded run on a sample. It is not an assessment of any production system, not a
certification, and not a signed attestation. The accompanying `manifest.json` records SHA-256
hashes so a recipient can detect a changed file. The manifest is not a signature and not an
attestation; it does not prove who produced the artifact.

## What this is not

- Not a vendor integration, partnership or endorsement.
- Not legal, tax, clinical, insurance or safety advice.
- Not a third-party audit, SOC 2 report, ISO certification or patent filing.
- Not a production write action: no downstream tool was called.

Prices and packaging are proposals. Built by a three-person team.