# Research Evidence Review

**SKU:** CAIN-A75-012  
**Development:** #12 Experimentally validated biological binder discovery  
**Product status:** DELIVERABLE  
**Engine:** `binder_evidence` (`cain_a75_engines/binderevidence/engine.py`)  
**Profile:** `il6_binder`  
**Generated:** 2026-11-12T07:59:12Z UTC

## Result

VERIFIED: controls, curve fit, potency, replicate CV, selectivity and independent replication recomputed; 21/21 evidence-failure cases as expected

- **il6_binder_evidence**: VERIFIED
- **honest_supported_binder**: SUPPORTED
- **too_few_replicates**: NOT_SUPPORTED
- **positive_control_failed**: NOT_SUPPORTED
- **negative_control_failed**: NOT_SUPPORTED
- **blanks_not_subtracted**: NOT_SUPPORTED
- **poor_curve_fit**: NOT_SUPPORTED
- **kd_too_weak**: NOT_SUPPORTED
- **replicate_cv_too_high**: NOT_SUPPORTED
- **headline_kd_does_not_match**: NOT_SUPPORTED
- **off_target_too_close**: NOT_SUPPORTED
- **off_target_flagged**: NOT_SUPPORTED
- **no_independent_replication**: NOT_SUPPORTED
- **replication_different_protocol**: NOT_SUPPORTED
- **replication_diverges**: NOT_SUPPORTED
- **invalid_sequence**: NOT_SUPPORTED
- **missing_protocol_hash**: NOT_SUPPORTED
- **missing_raw_data_hash**: NOT_SUPPORTED
- **claim_overstates_validation**: NOT_SUPPORTED
- **unknown_claim**: NOT_SUPPORTED
- **wrong_schema**: NOT_SUPPORTED
- **garbage**: NOT_SUPPORTED

## Limits of this run

Reviews supplied measurements. It does not run an assay, and it does not prove the binder works in an organism. A fabricated record can look consistent. The run is Ed25519-signed; pin the issuer key out of band.

This is a bounded run on a sample. It is not an assessment of any production system, not a
certification, and not a signed attestation. The accompanying `manifest.json` records SHA-256
hashes so a recipient can detect a changed file. The manifest is not a signature and not an
attestation; it does not prove who produced the artifact.

## What this is not

- Not a vendor integration, partnership or endorsement.
- Not legal, tax, clinical, insurance or safety advice.
- Not a third-party audit, SOC 2 report, ISO certification or patent filing.
- Not a production write action: no downstream tool was called.

Prices and packaging are proposals. Built by a three-person team.